Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses
Pancreatic α-cells secrete glucagon, an insulin counter-regulatory peptide hormone critical for the maintenance of glucose homeostasis. Investigation of the function of human α-cells remains a challenge due to the lack of cost-effective purification methods to isolate high-quality α-cells from islet...
Main Authors: | Sevim Kahraman, Kimitaka Shibue, Dario F De Jesus, Hyunki Kim, Jiang Hu, Debasish Manna, Bridget Wagner, Amit Choudhary, Rohit N Kulkarni |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2023-09-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/85056 |
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