Defining the Magnetic Resonance Features of Renal Lesions and Their Response to Everolimus in a Transgenic Mouse Model of Tuberous Sclerosis Complex

Defining the Magnetic Resonance Features of Renal Lesions and Their Response to Everolimus in a Transgenic Mouse Model of Tuberous Sclerosis Complex

Tuberous sclerosis complex (TSC) is an inherited genetic disorder characterized by mutations in TSC1 or TSC2 class of tumor suppressers which impact several organs including the kidney. The renal manifestations are usually in the form of angiomyolipoma (AML, in 80% of the cases) and cystadenomas. mT...

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Bibliographic Details
Main Authors: Shubhangi Agarwal, Emilie Decavel-Bueff, Yung-Hua Wang, Hecong Qin, Romelyn Delos Santos, Michael J. Evans, Renuka Sriram
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
TSC
kidney
everolimus
mTOR
MRI
mp-MRI
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.851192/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.851192/full

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