Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Angiopoietin-like protein (ANGPTL)3 regulates plasma lipids by inhibiting LPL and endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical LDLR-mediated pathway and represents a promising therapeutic approach for individuals with homozygous familial hypercholesterole...

Full description

Bibliographic Details
Main Authors: Rene C. Adam, Ivory J. Mintah, Corey A. Alexa-Braun, Lisa M. Shihanian, Joseph S. Lee, Poulabi Banerjee, Sara C. Hamon, Hye In Kim, Jonathan C. Cohen, Helen H. Hobbs, Cristopher Van Hout, Jesper Gromada, Andrew J. Murphy, George D. Yancopoulos, Mark W. Sleeman, Viktoria Gusarova
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
cardiovascular disease
familial hypercholesterolemia
low density lipoprotein-cholesterol
low density lipoprotein receptor
lipidomics
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520436922

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520436922

Similar Items