A systems biology model of junctional localization and downstream signaling of the Ang–Tie signaling pathway

Abstract The Ang–Tie signaling pathway is an important vascular signaling pathway regulating vascular growth and stability. Dysregulation in the pathway is associated with vascular dysfunction and numerous diseases that involve abnormal vascular permeability and endothelial cell inflammation. The un...

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Bibliographic Details
Main Authors: Yu Zhang, Christopher D. Kontos, Brian H. Annex, Aleksander S. Popel
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-021-00194-6