X chromosome inactivation in the human placenta is patchy and distinct from adult tissues

Summary: In humans, one of the X chromosomes in genetic females is inactivated by a process called X chromosome inactivation (XCI). Variation in XCI across the placenta may contribute to observed sex differences and variability in pregnancy outcomes. However, XCI has predominantly been studied in hu...

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Bibliographic Details
Main Authors: Tanya N. Phung, Kimberly C. Olney, Brendan J. Pinto, Michelle Silasi, Lauren Perley, Jane O’Bryan, Harvey J. Kliman, Melissa A. Wilson
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:HGG Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247722000379