Simultaneous detection of EGFR amplification and EGFRvIII variant using digital PCR-based method in glioblastoma

Simultaneous detection of EGFR amplification and EGFRvIII variant using digital PCR-based method in glioblastoma

Abstract Epidermal growth factor receptor (EGFR) amplification and EGFR variant III (EGFRvIII, deletion of exons 2–7) are of clinical interest for glioblastoma. The aim was to develop a digital PCR (dPCR)-based method using locked nucleic acid (LNA)-based hydrolysis probes, allowing the simultaneous...

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Bibliographic Details
Main Authors: Maxime Fontanilles, Florent Marguet, Philippe Ruminy, Carole Basset, Adrien Noel, Ludivine Beaussire, Mathieu Viennot, Pierre-Julien Viailly, Kevin Cassinari, Pascal Chambon, Doriane Richard, Cristina Alexandru, Isabelle Tennevet, Olivier Langlois, Frédéric Di Fiore, Annie Laquerrière, Florian Clatot, Nasrin Sarafan-Vasseur
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Acta Neuropathologica Communications
Subjects:
Glioblastoma
Digital PCR
EGFR amplification
EGFRvIII variant
Cost-effectiveness
Online Access:http://link.springer.com/article/10.1186/s40478-020-00917-6

Internet

http://link.springer.com/article/10.1186/s40478-020-00917-6

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