Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis

Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis

Abstract Gasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis remains largely unexplored. In this study, we demonstrate tha...

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Bibliographic Details
Main Authors: Weilv Xu, Qiao Jin, Xinyue Li, Danyue Li, Xinyu Fu, Nan Chen, Qian Lv, Yuhua Shi, Suhui He, Lu Dong, Yang Yang, Yuqi Yan, Fushan Shi
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06505-z

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https://doi.org/10.1038/s41419-024-06505-z

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