Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

Abstract Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are related RNA viruses responsible for severe respiratory infections and resulting disease in infants, elderly, and immunocompromised adults1–3. Therapeutic small molecule inhibitors that bind to the RSV polymerase and inhi...

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Bibliographic Details
Main Authors: Victoria A. Kleiner, Thierry O. Fischmann, John A. Howe, Douglas C. Beshore, Michael J. Eddins, Yan Hou, Todd Mayhood, Daniel Klein, Debbie D. Nahas, Bob J. Lucas, He Xi, Edward Murray, Daphne Y. Ma, Krista Getty, Rachel Fearns
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04990-0

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https://doi.org/10.1038/s42003-023-04990-0

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