Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A
Botulinum toxin A inhibits neuromuscular transmission. It has become a drug with many indications. The range of clinical applications has grown to encompass several neurological and non-neurological conditions. One of the most recent achievements in the field is the observation that botulinum toxin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-05-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/7/6/1882 |
| _version_ | 1811185108524204032 |
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| author | Giuseppe Brisinda Nicola Sivestrini Giuseppe Bianco Giorgio Maria |
| author_facet | Giuseppe Brisinda Nicola Sivestrini Giuseppe Bianco Giorgio Maria |
| author_sort | Giuseppe Brisinda |
| collection | DOAJ |
| description | Botulinum toxin A inhibits neuromuscular transmission. It has become a drug with many indications. The range of clinical applications has grown to encompass several neurological and non-neurological conditions. One of the most recent achievements in the field is the observation that botulinum toxin A provides benefit in diseases of the gastrointestinal tract. Although toxin blocks cholinergic nerve endings in the autonomic nervous system, it has also been shown that it does not block non-adrenergic non-cholinergic responses mediated by nitric oxide. This has promoted further interest in using botulinum toxin A as a treatment for overactive smooth muscles and sphincters. The introduction of this therapy has made the treatment of several clinical conditions easier, in the outpatient setting, at a lower cost and without permanent complications. This review presents current data on the use of botulinum toxin A in the treatment of pathological conditions of the gastrointestinal tract. |
| first_indexed | 2024-04-11T13:23:48Z |
| format | Article |
| id | doaj.art-b7781d0487c440508a9048be74c7cb4e |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T13:23:48Z |
| publishDate | 2015-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-b7781d0487c440508a9048be74c7cb4e2022-12-22T04:22:07ZengMDPI AGToxins2072-66512015-05-01761882191610.3390/toxins7061882toxins7061882Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin AGiuseppe Brisinda0Nicola Sivestrini1Giuseppe Bianco2Giorgio Maria3Department of Surgery, University Hospital "Agostino Gemelli", Largo Agostino Gemelli 8, 00168 Rome, ItalyDepartment of Surgery, University Hospital "Agostino Gemelli", Largo Agostino Gemelli 8, 00168 Rome, ItalyDepartment of Surgery, University Hospital "Agostino Gemelli", Largo Agostino Gemelli 8, 00168 Rome, ItalyDepartment of Surgery, University Hospital "Agostino Gemelli", Largo Agostino Gemelli 8, 00168 Rome, ItalyBotulinum toxin A inhibits neuromuscular transmission. It has become a drug with many indications. The range of clinical applications has grown to encompass several neurological and non-neurological conditions. One of the most recent achievements in the field is the observation that botulinum toxin A provides benefit in diseases of the gastrointestinal tract. Although toxin blocks cholinergic nerve endings in the autonomic nervous system, it has also been shown that it does not block non-adrenergic non-cholinergic responses mediated by nitric oxide. This has promoted further interest in using botulinum toxin A as a treatment for overactive smooth muscles and sphincters. The introduction of this therapy has made the treatment of several clinical conditions easier, in the outpatient setting, at a lower cost and without permanent complications. This review presents current data on the use of botulinum toxin A in the treatment of pathological conditions of the gastrointestinal tract.http://www.mdpi.com/2072-6651/7/6/1882anusphysiopathologyautonomic nervous system diseasesbiliary diseasesbotulinum toxintherapeutic usechronic constipationenteric nervous systemesophageal achalasiaesophageal diseasesexocytosisfissure-in-anogastric emptyinggastrointestinal motilitymembrane fusionmembrane proteinsneuromuscular agentsobesitypainspasm |
| spellingShingle | Giuseppe Brisinda Nicola Sivestrini Giuseppe Bianco Giorgio Maria Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A Toxins anus physiopathology autonomic nervous system diseases biliary diseases botulinum toxin therapeutic use chronic constipation enteric nervous system esophageal achalasia esophageal diseases exocytosis fissure-in-ano gastric emptying gastrointestinal motility membrane fusion membrane proteins neuromuscular agents obesity pain spasm |
| title | Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A |
| title_full | Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A |
| title_fullStr | Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A |
| title_full_unstemmed | Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A |
| title_short | Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A |
| title_sort | treatment of gastrointestinal sphincters spasms with botulinum toxin a |
| topic | anus physiopathology autonomic nervous system diseases biliary diseases botulinum toxin therapeutic use chronic constipation enteric nervous system esophageal achalasia esophageal diseases exocytosis fissure-in-ano gastric emptying gastrointestinal motility membrane fusion membrane proteins neuromuscular agents obesity pain spasm |
| url | http://www.mdpi.com/2072-6651/7/6/1882 |
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