Inhibition of Ribosome Assembly and Ribosome Translation Has Distinctly Different Effects on Abundance and Paralogue Composition of Ribosomal Protein mRNAs in Saccharomyces cerevisiae

Inhibition of Ribosome Assembly and Ribosome Translation Has Distinctly Different Effects on Abundance and Paralogue Composition of Ribosomal Protein mRNAs in Saccharomyces cerevisiae

ABSTRACT Many mutations in genes for ribosomal proteins (r-proteins) and assembly factors cause cell stress and altered cell fate, resulting in congenital diseases collectively called ribosomopathies. Even though all such mutations depress the cell’s protein synthesis capacity, they generate many di...

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Bibliographic Details
Main Authors: Md Shamsuzzaman, Nusrat Rahman, Brian Gregory, Ananth Bommakanti, Janice M. Zengel, Vincent M. Bruno, Lasse Lindahl
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mSystems
Subjects:
cell stress
nucleolar stress
ribosomal protein paralogues
ribosomal proteins
ribosome biogenesis
transcriptome
Online Access:https://journals.asm.org/doi/10.1128/msystems.01098-22

Internet

https://journals.asm.org/doi/10.1128/msystems.01098-22

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