Inhibition of Ribosome Assembly and Ribosome Translation Has Distinctly Different Effects on Abundance and Paralogue Composition of Ribosomal Protein mRNAs in Saccharomyces cerevisiae
ABSTRACT Many mutations in genes for ribosomal proteins (r-proteins) and assembly factors cause cell stress and altered cell fate, resulting in congenital diseases collectively called ribosomopathies. Even though all such mutations depress the cell’s protein synthesis capacity, they generate many di...
Main Authors: | Md Shamsuzzaman, Nusrat Rahman, Brian Gregory, Ananth Bommakanti, Janice M. Zengel, Vincent M. Bruno, Lasse Lindahl |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2023-02-01
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Series: | mSystems |
Subjects: | |
Online Access: | https://journals.asm.org/doi/10.1128/msystems.01098-22 |
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