Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway

Endothelial inflammation caused by tobacco smoking is widely considered as a pathogenic factor in many vascular diseases. Drugs such as atorvastatin were found to be an effective treatment in smoking-dependent vascular diseases, but the underlying mechanism is still unclear. Here, we investigated th...

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Main Authors: Hongbo Wang, Jiangyan Yin, Yi Guo
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Clinical and Experimental Hypertension
Subjects:
Online Access:http://dx.doi.org/10.1080/10641963.2018.1433196
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author Hongbo Wang
Jiangyan Yin
Yi Guo
author_facet Hongbo Wang
Jiangyan Yin
Yi Guo
author_sort Hongbo Wang
collection DOAJ
description Endothelial inflammation caused by tobacco smoking is widely considered as a pathogenic factor in many vascular diseases. Drugs such as atorvastatin were found to be an effective treatment in smoking-dependent vascular diseases, but the underlying mechanism is still unclear. Here, we investigated the mechanism of atorvastatin resisting endothelial inflammation caused by tobacco smoking. Firstly, isolated human umbilical vein endothelial cells (HUVECs) were divided into normal control group, cigarette smoking extract (CSE) group, and atorvastatin (AS)+CSE group. Then the expressions of inflammatory factors (vascular cell adhesion molecule-1 (VCAM-1) and E-selectin) and nuclear transcription factor kappa (NF-κB) in HUVECs were detected by western blot after separate treatments. The results showed that the expressions of VCAM-1, E-selectin, and NF-κB in CSE group were significantly higher than the other two groups (P< 0.05). We also found that the expressions of VCAM-1, E-selectin, and NF-κB in CSE + atorvastatin group were a little higher than the normal control group (P< 0.05). Our results showed that atorvastatin might partly resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway.
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spelling doaj.art-b77a8e69998d4365a775e83a286378b62023-09-19T15:19:27ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062019-01-014111410.1080/10641963.2018.14331961433196Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathwayHongbo Wang0Jiangyan Yin1Yi Guo2Chongqing Traditional Chinese Medicine HospitalThe First Affiliated Hospital of Chongqing Medical UniversityChongqing Traditional Chinese Medicine HospitalEndothelial inflammation caused by tobacco smoking is widely considered as a pathogenic factor in many vascular diseases. Drugs such as atorvastatin were found to be an effective treatment in smoking-dependent vascular diseases, but the underlying mechanism is still unclear. Here, we investigated the mechanism of atorvastatin resisting endothelial inflammation caused by tobacco smoking. Firstly, isolated human umbilical vein endothelial cells (HUVECs) were divided into normal control group, cigarette smoking extract (CSE) group, and atorvastatin (AS)+CSE group. Then the expressions of inflammatory factors (vascular cell adhesion molecule-1 (VCAM-1) and E-selectin) and nuclear transcription factor kappa (NF-κB) in HUVECs were detected by western blot after separate treatments. The results showed that the expressions of VCAM-1, E-selectin, and NF-κB in CSE group were significantly higher than the other two groups (P< 0.05). We also found that the expressions of VCAM-1, E-selectin, and NF-κB in CSE + atorvastatin group were a little higher than the normal control group (P< 0.05). Our results showed that atorvastatin might partly resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway.http://dx.doi.org/10.1080/10641963.2018.1433196vascular endothelial cellstobacco smokingnuclear transcription factor kappa b(nf-κb) signal pathwayvascular cell adhesion molecule-1(vcam-1)e-selectin
spellingShingle Hongbo Wang
Jiangyan Yin
Yi Guo
Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway
Clinical and Experimental Hypertension
vascular endothelial cells
tobacco smoking
nuclear transcription factor kappa b(nf-κb) signal pathway
vascular cell adhesion molecule-1(vcam-1)
e-selectin
title Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway
title_full Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway
title_fullStr Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway
title_full_unstemmed Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway
title_short Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway
title_sort atorvastatin might resist tobacco smoking induced endothelial inflammation through the inhibition of nf κb signal pathway
topic vascular endothelial cells
tobacco smoking
nuclear transcription factor kappa b(nf-κb) signal pathway
vascular cell adhesion molecule-1(vcam-1)
e-selectin
url http://dx.doi.org/10.1080/10641963.2018.1433196
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