Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway
Endothelial inflammation caused by tobacco smoking is widely considered as a pathogenic factor in many vascular diseases. Drugs such as atorvastatin were found to be an effective treatment in smoking-dependent vascular diseases, but the underlying mechanism is still unclear. Here, we investigated th...
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Format: | Article |
Language: | English |
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Taylor & Francis Group
2019-01-01
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Series: | Clinical and Experimental Hypertension |
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Online Access: | http://dx.doi.org/10.1080/10641963.2018.1433196 |
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author | Hongbo Wang Jiangyan Yin Yi Guo |
author_facet | Hongbo Wang Jiangyan Yin Yi Guo |
author_sort | Hongbo Wang |
collection | DOAJ |
description | Endothelial inflammation caused by tobacco smoking is widely considered as a pathogenic factor in many vascular diseases. Drugs such as atorvastatin were found to be an effective treatment in smoking-dependent vascular diseases, but the underlying mechanism is still unclear. Here, we investigated the mechanism of atorvastatin resisting endothelial inflammation caused by tobacco smoking. Firstly, isolated human umbilical vein endothelial cells (HUVECs) were divided into normal control group, cigarette smoking extract (CSE) group, and atorvastatin (AS)+CSE group. Then the expressions of inflammatory factors (vascular cell adhesion molecule-1 (VCAM-1) and E-selectin) and nuclear transcription factor kappa (NF-κB) in HUVECs were detected by western blot after separate treatments. The results showed that the expressions of VCAM-1, E-selectin, and NF-κB in CSE group were significantly higher than the other two groups (P< 0.05). We also found that the expressions of VCAM-1, E-selectin, and NF-κB in CSE + atorvastatin group were a little higher than the normal control group (P< 0.05). Our results showed that atorvastatin might partly resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway. |
first_indexed | 2024-03-11T23:44:18Z |
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id | doaj.art-b77a8e69998d4365a775e83a286378b6 |
institution | Directory Open Access Journal |
issn | 1064-1963 1525-6006 |
language | English |
last_indexed | 2024-03-11T23:44:18Z |
publishDate | 2019-01-01 |
publisher | Taylor & Francis Group |
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series | Clinical and Experimental Hypertension |
spelling | doaj.art-b77a8e69998d4365a775e83a286378b62023-09-19T15:19:27ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062019-01-014111410.1080/10641963.2018.14331961433196Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathwayHongbo Wang0Jiangyan Yin1Yi Guo2Chongqing Traditional Chinese Medicine HospitalThe First Affiliated Hospital of Chongqing Medical UniversityChongqing Traditional Chinese Medicine HospitalEndothelial inflammation caused by tobacco smoking is widely considered as a pathogenic factor in many vascular diseases. Drugs such as atorvastatin were found to be an effective treatment in smoking-dependent vascular diseases, but the underlying mechanism is still unclear. Here, we investigated the mechanism of atorvastatin resisting endothelial inflammation caused by tobacco smoking. Firstly, isolated human umbilical vein endothelial cells (HUVECs) were divided into normal control group, cigarette smoking extract (CSE) group, and atorvastatin (AS)+CSE group. Then the expressions of inflammatory factors (vascular cell adhesion molecule-1 (VCAM-1) and E-selectin) and nuclear transcription factor kappa (NF-κB) in HUVECs were detected by western blot after separate treatments. The results showed that the expressions of VCAM-1, E-selectin, and NF-κB in CSE group were significantly higher than the other two groups (P< 0.05). We also found that the expressions of VCAM-1, E-selectin, and NF-κB in CSE + atorvastatin group were a little higher than the normal control group (P< 0.05). Our results showed that atorvastatin might partly resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway.http://dx.doi.org/10.1080/10641963.2018.1433196vascular endothelial cellstobacco smokingnuclear transcription factor kappa b(nf-κb) signal pathwayvascular cell adhesion molecule-1(vcam-1)e-selectin |
spellingShingle | Hongbo Wang Jiangyan Yin Yi Guo Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway Clinical and Experimental Hypertension vascular endothelial cells tobacco smoking nuclear transcription factor kappa b(nf-κb) signal pathway vascular cell adhesion molecule-1(vcam-1) e-selectin |
title | Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway |
title_full | Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway |
title_fullStr | Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway |
title_full_unstemmed | Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway |
title_short | Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-κB signal pathway |
title_sort | atorvastatin might resist tobacco smoking induced endothelial inflammation through the inhibition of nf κb signal pathway |
topic | vascular endothelial cells tobacco smoking nuclear transcription factor kappa b(nf-κb) signal pathway vascular cell adhesion molecule-1(vcam-1) e-selectin |
url | http://dx.doi.org/10.1080/10641963.2018.1433196 |
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