Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation

Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation

Abstract During obesity, macrophages can infiltrate metabolic tissues, and contribute to chronic low-grade inflammation, and mediate insulin resistance and diabetes. Recent studies have elucidated the metabolic role of JAK2, a key mediator downstream of various cytokines and growth factors. Our stud...

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Bibliographic Details
Main Authors: Harsh R. Desai, Tharini Sivasubramaniyam, Xavier S. Revelo, Stephanie A. Schroer, Cynthia T. Luk, Prashanth R. Rikkala, Adam H. Metherel, David W. Dodington, Yoo Jin Park, Min Jeong Kim, Joshua A. Rapps, Rickvinder Besla, Clinton S. Robbins, Kay-Uwe Wagner, Richard P. Bazinet, Daniel A. Winer, Minna Woo
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07923-0

Internet

https://doi.org/10.1038/s41598-017-07923-0

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