Corylifol A suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via attenuating ROS production and impairing mitochondrial function

Corylifol A suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via attenuating ROS production and impairing mitochondrial function

Osteoporosis is a systemic disease characterized by an imbalance in bone homeostasis, where osteoblasts fail to fully compensate for the bone resorption induced by osteoclasts. Corylifol A, a flavonoid extracted from Fructus psoraleae, has been identified as a potential treatment for this condition....

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Bibliographic Details
Main Authors: HaiShan Li, Wei Deng, JiaMin Yang, YueWei Lin, ShiYin Zhang, ZiXuan Liang, JunChun Chen, MinHua Hu, Teng Liu, GuoYe Mo, Zhen Zhang, DongPing Wang, Peng Gu, YongChao Tang, Kai Yuan, LiangLiang Xu, JiaKe Xu, ShunCong Zhang, YongXian Li
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Corylifol A
Osteoclastogenesis
PI3K-AKT
Reactive oxygen species
Oxidative phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224000477

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http://www.sciencedirect.com/science/article/pii/S0753332224000477

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