Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation

Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation

The potential translation of bio-inert polymer scaffolds as bone substitutes is limited by the lack of neovascularization upon implantation and subsequently diminished ingrowth of host bone, most likely resulted from the inability to replicate appropriate endogenous crosstalk between cells. Human um...

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Bibliographic Details
Main Authors: Yijun He, Wenhao Wang, Shaozhang Lin, Yixi Yang, Lizhi Song, Yihan Jing, Lihao Chen, Zaopeng He, Wei Li, Ao Xiong, Kelvin W.K. Yeung, Qi Zhao, Yuan Jiang, Zijie Li, Guoxian Pei, Zhi-Yong Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-03-01
Series:Bioactive Materials
Subjects:
Cell-derived decellularized extracellular matrix
Microenvironment
Vascularized bone regeneration
Type H vessels
Osseointegration
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21003625

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http://www.sciencedirect.com/science/article/pii/S2452199X21003625

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