Molecular and structural basis of actin filament severing by ADF/cofilin

Molecular and structural basis of actin filament severing by ADF/cofilin

ADF/cofilin’s cooperative binding to actin filament modifies the conformation and alignment of G-actin subunits locally, causing the filament to sever at “boundaries” formed among bare and ADF/cofilin-occupied regions. Analysis of the impact of the ADF/cofilin cluster boundary on the deformation beh...

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Bibliographic Details
Main Authors: Sharad V. Jaswandkar, Kalpana S. Katti, Dinesh R. Katti
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Actin
ADF/cofilin
molecular dynamics
actin dynamics
cytoskeleton
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022003348

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http://www.sciencedirect.com/science/article/pii/S2001037022003348

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