A positive feedback loop between ID3 and PPARγ via DNA damage repair regulates the efficacy of radiotherapy for rectal cancer

A positive feedback loop between ID3 and PPARγ via DNA damage repair regulates the efficacy of radiotherapy for rectal cancer

Abstract Objective To study the effect of inhibitor of differentiation 3 (ID3) on radiotherapy in patients with rectal cancer and to explore its primary mechanism. Methods Cell proliferation and clonogenic assays were used to study the relationship between ID3 and radiosensitivity. Co-immunoprecipit...

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Bibliographic Details
Main Authors: Chuanzhong Huang, Ling Wang, Huijing Chen, Wankai Fu, Lingdong Shao, Dongmei Zhou, Junxin Wu, Yunbin Ye
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Cancer
Subjects:
ID3
PPARγ
Radiotherapy efficacy
Positive feedback
Rectal cancer
Online Access:https://doi.org/10.1186/s12885-023-10874-7

Internet

https://doi.org/10.1186/s12885-023-10874-7

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