Internal Ribosome Entry Site (IRES)-Mediated Translation and Its Potential for Novel mRNA-Based Therapy Development

Many conditions can benefit from RNA-based therapies, namely, those targeting internal ribosome entry sites (IRESs) and their regulatory proteins, the IRES <i>trans</i>-acting factors (ITAFs). IRES-mediated translation is an alternative mechanism of translation initiation, known for main...

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Bibliographic Details
Main Authors: Rita Marques, Rafaela Lacerda, Luísa Romão
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
Online Access:https://www.mdpi.com/2227-9059/10/8/1865