Dependency of EGFR activation in vanadium-based sensitization to oncolytic virotherapy

Dependency of EGFR activation in vanadium-based sensitization to oncolytic virotherapy

Oncolytic virotherapy is a clinically validated approach to treat cancers such as melanoma; however, tumor resistance to virus makes its efficacy variable. Compounds such as sodium orthovanadate (vanadate) can overcome viral resistance and synergize with RNA-based oncolytic viruses. In this study, w...

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Bibliographic Details
Main Authors: Boaz Wong, Anabel Bergeron, Nouf Alluqmani, Glib Maznyi, Andrew Chen, Rozanne Arulanandam, Jean-Simon Diallo
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
EGFR
oncolytic virotherapy
vanadium
interferon
cell signaling
viral sensitization
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522000560

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http://www.sciencedirect.com/science/article/pii/S2372770522000560

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