Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C‐reactive protein in white British population

Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C‐reactive protein in white British population

Abstract Background C‐reactive protein (CRP) is a sensitive biomarker of inflammation with moderate heritability. The role of rare functional genetic variants in relation to serum CRP is understudied. We aimed to examine gene mutation burden of protein‐altering (PA) and loss‐of‐function (LOF) varian...

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Bibliographic Details
Main Authors: Xia Li, Alexander Ploner, Yunzhang Wang, Jonathan K. L. Mak, Yi Lu, Patrik K. E. Magnusson, Juulia Jylhävä, Sara Hägg
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
C‐reactive protein
loss‐of‐function variants
obesity
protein‐altering variants
rare genetic variants
UK Biobank
Online Access:https://doi.org/10.1002/mgg3.2255

Internet

https://doi.org/10.1002/mgg3.2255

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