Poly-L-ornithine blocks the inhibitory effects of fibronectin on oligodendrocyte differentiation and promotes myelin repair

Poly-L-ornithine blocks the inhibitory effects of fibronectin on oligodendrocyte differentiation and promotes myelin repair

The extracellular matrix surrounding oligodendrocytes plays an important role during myelination and remyelination in the brain. In many cases, the microenvironment surrounding demyelination lesions contains inhibitory molecules, which lead to repair failure. Accordingly, blocking the activity of th...

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Bibliographic Details
Main Authors: Ya-Jie Xiong, Shahid Hussain Soomro, Zhong-Hai Huang, Pan-Pan Yu, Jie Ping, Hui Fu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Neural Regeneration Research
Subjects:
differentiation; erk1/2; extracellular matrix; fibronectin; lysolecithin-induced demyelination; oligodendrocyte; pi3k; poly-l-ornithine; proliferation; remyelination
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=4;spage=832;epage=839;aulast=Xiong

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=4;spage=832;epage=839;aulast=Xiong

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