Evaluation of In Vitro Activity of Double-Carbapenem Combinations against KPC-2-, OXA-48- and NDM-Producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>

Evaluation of In Vitro Activity of Double-Carbapenem Combinations against KPC-2-, OXA-48- and NDM-Producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>

Double-carbapenem combinations have shown synergistic potential against carbapenemase-producing <i>Enterobacterales,</i> but data remain inconclusive. This study evaluated the activity of double-carbapenem combinations against 51 clinical KPC-2-, OXA-48-, NDM-1, and NDM-5-producing <i...

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Bibliographic Details
Main Authors: Lisa Allander, Karin Vickberg, Pernilla Lagerbäck, Linus Sandegren, Thomas Tängdén
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Antibiotics
Subjects:
carbapenem resistance
Gram-negative bacteria
combination therapy
synergy
Online Access:https://www.mdpi.com/2079-6382/11/11/1646

Internet

https://www.mdpi.com/2079-6382/11/11/1646

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