mTOR pathway gene mutations predict response to immune checkpoint inhibitors in multiple cancers

mTOR pathway gene mutations predict response to immune checkpoint inhibitors in multiple cancers

Abstract Background mTOR pathway is known to promote cancer malignancy and influence cancer immunity but is unknown for its role in immune checkpoint inhibitors (ICI) therapy. Methods Using Memorial Sloan-Kettering Cancer Center dataset (MSKCC), we extracted mTOR pathway gene mutations for stepwise...

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Bibliographic Details
Main Authors: Lei Cheng, Yanan Wang, Lixin Qiu, Yuanyuan Chang, Haijiao Lu, Chenchen Liu, Bo Zhang, Yan Zhou, Hao Bai, Liwen Xiong, Hua Zhong, Wei Nie, Baohui Han
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Translational Medicine
Subjects:
mTOR pathway
Cancer
ICI
TMB
Prognosis
Online Access:https://doi.org/10.1186/s12967-022-03436-1

Internet

https://doi.org/10.1186/s12967-022-03436-1

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