Quantification of Cardiotonic Steroids Potentially Regulated by Paraoxonase 3 in a Rat Model of Chronic Kidney Disease Using UHPLC-Orbitrap-MS

Quantification of Cardiotonic Steroids Potentially Regulated by Paraoxonase 3 in a Rat Model of Chronic Kidney Disease Using UHPLC-Orbitrap-MS

Endogenous cardiotonic steroids (CTSs), such as telocinobufagin (TCB) and marinobufagin (MBG) contain a lactone moiety critical to their binding and signaling through the Na<sup>+</sup>/K<sup>+</sup>-ATPase. Their concentrations elevate in response to sodium intake and under...

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Bibliographic Details
Main Authors: Sabitri Lamichhane, Chrysan J. Mohammed, Steven T. Haller, David J. Kennedy, Dragan Isailovic
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
endogenous cardiotonic steroids
telocinobufagin
marinobufagin
paraoxonase
urine
SPE
Online Access:https://www.mdpi.com/1422-0067/23/21/13565

Internet

https://www.mdpi.com/1422-0067/23/21/13565

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