Discovery of GOT1 Inhibitors from a Marine-Derived <i>Aspergillus terreus</i> That Act against Pancreatic Ductal Adenocarcinoma

Discovery of GOT1 Inhibitors from a Marine-Derived <i>Aspergillus terreus</i> That Act against Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a devastating digestive system carcinoma with high incidence and death rates. PDAC cells are dependent on the Gln metabolism, which can preferentially utilize glutamic oxaloacetate transaminase 1 (GOT1) to maintain the redox homeostasis of cancer cells. The...

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Bibliographic Details
Main Authors: Shan Yan, Changxing Qi, Wei Song, Qianqian Xu, Lianghu Gu, Weiguang Sun, Yonghui Zhang
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Marine Drugs
Subjects:
natural products
GOT1 enzyme
X-ray crystallography
pancreatic ductal adenocarcinoma cells
glutamine metabolism
Online Access:https://www.mdpi.com/1660-3397/19/11/588

Internet

https://www.mdpi.com/1660-3397/19/11/588

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