Indoxyl Sulfate Contributes to mTORC1-Induced Renal Fibrosis via The OAT/NADPH Oxidase/ROS Pathway

Indoxyl Sulfate Contributes to mTORC1-Induced Renal Fibrosis via The OAT/NADPH Oxidase/ROS Pathway

Activation of mTORC1 (mechanistic target of rapamycin complex 1) in renal tissue has been reported in chronic kidney disease (CKD)-induced renal fibrosis. However, the molecular mechanisms responsible for activating mTORC1 in CKD pathology are not well understood. The purpose of this study was to id...

Full description

Bibliographic Details
Main Authors: Takehiro Nakano, Hiroshi Watanabe, Tadashi Imafuku, Kai Tokumaru, Issei Fujita, Nanaka Arimura, Hitoshi Maeda, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Toxins
Subjects:
indoxyl sulfate
chronic kidney disease
renal fibrosis
mTORC1
AST-120
Online Access:https://www.mdpi.com/2072-6651/13/12/909

Internet

https://www.mdpi.com/2072-6651/13/12/909

Similar Items