Fluorinated hyaluronates endow oral nanoparticles with mucus penetration and colonic macrophage targeting properties

Fluorinated hyaluronates endow oral nanoparticles with mucus penetration and colonic macrophage targeting properties

The therapeutic outcomes of oral nanotherapeutics against ulcerative colitis (UC) are compromised by their shortage of mucus-penetrating and macrophage-targeting properties. Herein, hyaluronate (HA) was fluorinated and used to functionalize the surface of curcumin (CUR)-loaded polymeric nanoparticle...

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Bibliographic Details
Main Authors: Yuqi Liang, Qian He, Lian Duan, Hanlin Gong, Menghang Zu, Dengchao Xie, Bo Xiao
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-01-01
Series:Smart Materials in Medicine
Subjects:
Fluorination
Hyaluronate
Oral nanoparticle
Mucus penetration
Macrophage targeting
Ulcerative colitis
Online Access:http://www.sciencedirect.com/science/article/pii/S2590183421000156

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http://www.sciencedirect.com/science/article/pii/S2590183421000156

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