A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Glycosylated biopharmaceuticals are important in the global pharmaceutical market. Despite the importance of their glycan structures, our limited knowledge of the glycosylation machinery still hinders controllability of this critical quality attribute. To facilitate discovery of glycosyltransferase...

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Bibliographic Details
Main Authors: Chenguang Liang, Austin W.T. Chiang, Anders H. Hansen, Johnny Arnsdorf, Sanne Schoffelen, James T. Sorrentino, Benjamin P. Kellman, Bokan Bao, Bjørn G. Voldborg, Nathan E. Lewis
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Current Research in Biotechnology
Subjects:
Glycosylation model
Glycomics
Systems glycobiology
Glycoengineering
Isozyme specificity
Glycosyltransferase interactions
Online Access:http://www.sciencedirect.com/science/article/pii/S2590262820300010

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http://www.sciencedirect.com/science/article/pii/S2590262820300010

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