Increased BMSC exosomal miR-140-3p alleviates bone degradation and promotes bone restoration by targeting Plxnb1 in diabetic rats

Increased BMSC exosomal miR-140-3p alleviates bone degradation and promotes bone restoration by targeting Plxnb1 in diabetic rats

Abstract Background Diabetes mellitus (DM) is considered to be an important factor for bone degeneration disorders such as bone defect nonunion, which is characterized by physical disability and tremendous economy cost to families and society. Exosomal miRNAs of BMSCs have been reported to participa...

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Bibliographic Details
Main Authors: Ning Wang, Xuanchen Liu, Zhen Tang, Xinghui Wei, Hui Dong, Yichao Liu, Hao Wu, Zhigang Wu, Xiaokang Li, Xue Ma, Zheng Guo
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Nanobiotechnology
Subjects:
Bone defect
Diabetes mellitus
Exosomes
MiR-140-3p
Plexin B1
Online Access:https://doi.org/10.1186/s12951-022-01267-2

Internet

https://doi.org/10.1186/s12951-022-01267-2

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