P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis.

ATP-mediated signaling is an important regulator of electrolyte transport in the kidney. The purinergic cation channel P2X6 has been previously localized to the distal convoluted tubule (DCT), a nephron segment important for Mg2+ and Na+ reabsorption, but its role in ion transport remains unknown. I...

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Bibliographic Details
Main Authors: Jeroen H F de Baaij, Andreas Kompatscher, Daan H H M Viering, Caro Bos, René J M Bindels, Joost G J Hoenderop
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4890750?pdf=render