Comparative immunogenicity of an mRNA/LNP and a DNA vaccine targeting HIV gag conserved elements in macaques

Comparative immunogenicity of an mRNA/LNP and a DNA vaccine targeting HIV gag conserved elements in macaques

Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) formulation expressing HIV-1 Gag and Gag conserved regions (CE) as immunogens developed robust, durable antibody responses but low adap...

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Bibliographic Details
Main Authors: Antonio Valentin, Cristina Bergamaschi, Margherita Rosati, Matthew Angel, Robert Burns, Mahesh Agarwal, Janina Gergen, Benjamin Petsch, Lidia Oostvogels, Edde Loeliger, Kara W. Chew, Steven G. Deeks, James I. Mullins, George N. Pavlakis, Barbara K. Felber
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
mRNA/LNP
therapeutic immunization
HIV
T cell response
antibody
gag
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.945706/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.945706/full

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