Low-dose oral cyclophosphamide therapy reduces atherosclerosis progression by decreasing inflammatory cells in a murine model of atherosclerosis

Background: Atherosclerosis is a chronic inflammatory disease responsible for most cases of heart disease and stroke in Western countries. The cytotoxic drug cyclophosphamide (CPA) can modulate immune functions, and it has therefore been used to treat patients with autoimmune diseases. Extension of...

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Bibliographic Details
Main Authors: Yayoi Sato-Okabayashi, Kikuo Isoda, Beate Heissig, Tomoyasu Kadoguchi, Koji Akita, Kenichi Kitamura, Kazunori Shimada, Koichi Hattori, Hiroyuki Daida
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:International Journal of Cardiology: Heart & Vasculature
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352906719302891