Polygenic hazard score modified the relationship between hippocampal subfield atrophy and episodic memory in older adults

Polygenic hazard score modified the relationship between hippocampal subfield atrophy and episodic memory in older adults

BackgroundUnderstanding genetic influences on Alzheimer’s disease (AD) may improve early identification. Polygenic hazard score (PHS) is associated with the age of AD onset and cognitive decline. It interacts with other risk factors, but the nature of such combined effects remains poorly understood....

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Bibliographic Details
Main Authors: Jingjing Xu, Xiaojun Guan, Jiaqi Wen, Minming Zhang, Xiaojun Xu, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
hippocampus subfield
episodic memory
polygenic hazard score
volume ratio
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.943702/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.943702/full

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