Impact of Oxidative DNA Damage and the Role of DNA Glycosylases in Neurological Dysfunction

The human brain requires a high rate of oxygen consumption to perform intense metabolic activities, accounting for 20% of total body oxygen consumption. This high oxygen uptake results in the generation of free radicals, including reactive oxygen species (ROS), which, at physiological levels, are be...

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Bibliographic Details
Main Authors: Mirta Mittelstedt Leal de Sousa, Jing Ye, Luisa Luna, Gunn Hildrestrand, Karine Bjørås, Katja Scheffler, Magnar Bjørås
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/22/23/12924