Characterization, molecular modeling and pharmacology of some 2́-hydroxychalcone derivatives as SARS-CoV-2 inhibitor

Characterization, molecular modeling and pharmacology of some 2́-hydroxychalcone derivatives as SARS-CoV-2 inhibitor

This work presented the microwave assisted synthesis of six new 2́-hydroxychalcones and their characterization based on FTIR, UV–Vis, 1H NMR, and mass spectral analysis. Quantum chemical studies confirmed the structures of prepared chalcones. Antioxidant, in vitro antimicrobial and in silico antivir...

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Bibliographic Details
Main Authors: Mohammad Nasir Uddin, Sayeda Samina Ahmed, Monir Uzzaman, Md. Nazmul Hassan Knock, Wahhida Shumi, Abul Fazal Md. Sanaullah, Md. Mosharef Hossain Bhuyain
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Results in Chemistry
Subjects:
2-Hydroxychalcones
Antimicrobial and antioxidant assessment
SARS-CoV-2 main protease
Molecular docking
Dynamics
ADMET prediction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715622000480

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http://www.sciencedirect.com/science/article/pii/S2211715622000480

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