Crucial role of TSC-22 in preventing the proteasomal degradation of p53 in cervical cancer.

Crucial role of TSC-22 in preventing the proteasomal degradation of p53 in cervical cancer.

The p53 tumor suppressor function can be compromised in many tumors by the cellular antagonist HDM2 and human papillomavirus oncogene E6 that induce p53 degradation. Restoration of p53 activity has strong therapeutic potential. Here, we identified TSC-22 as a novel p53-interacting protein and show i...

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Bibliographic Details
Main Authors: Cheol-Hee Yoon, Seung Bae Rho, Seong-Tae Kim, Seongho Kho, Junsoo Park, Ik-Soon Jang, Seonock Woo, Sung Soon Kim, Je-Ho Lee, Seung-Hoon Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3411576?pdf=render

Internet

http://europepmc.org/articles/PMC3411576?pdf=render

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