Effect of Phyllanthus amarus Extract on 5-Fluorouracil-Induced Perturbations in Ribonucleotide and Deoxyribonucleotide Pools in HepG2 Cell Line

Effect of Phyllanthus amarus Extract on 5-Fluorouracil-Induced Perturbations in Ribonucleotide and Deoxyribonucleotide Pools in HepG2 Cell Line

The aim of this study was to investigate the antitumor activities of Phyllanthus amarus (PHA) and its potential of herb–drug interactions with 5-Fluorouracil (5-FU). Cell viability, ribonucleotides (RNs) and deoxyribonucleotides (dRNs) levels, cell cycle distribution, and expression of thymidylate s...

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Bibliographic Details
Main Authors: Jian-Ru Guo, Qian-Qian Chen, Christopher Wai-Kei Lam, Cai-Yun Wang, Feng-Guo Xu, Bu-Ming Liu, Wei Zhang
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Molecules
Subjects:
Phyllanthus amarus extract
5-fluorouracil
ribonucleotides
deoxyribonucleotides
Online Access:http://www.mdpi.com/1420-3049/21/9/1254

Internet

http://www.mdpi.com/1420-3049/21/9/1254

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