Brain mGluR5 in Shank3B−/− Mice Studied With in vivo [18F]FPEB PET Imaging and ex vivo Immunoblotting

Brain mGluR5 in Shank3B−/− Mice Studied With in vivo [18F]FPEB PET Imaging and ex vivo Immunoblotting

Although several studies have found that metabotropic glutamate 5 receptor (mGluR5) may play an important role in autism spectrum disorders (ASD), the mechanisms remain unclear. Here, we used a Shank3 gene complete knockout mouse model (Shank3B−/−) to explore the change in mGluR5 in the brain. To as...

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Bibliographic Details
Main Authors: Guohong Cai, Mengmeng Wang, Shuailiang Wang, Yi Liu, Yan Zhao, Yuanyuan Zhu, Suo Zhao, Ming Zhang, Baolin Guo, Han Yao, Wenting Wang, Jing Wang, Shengxi Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Psychiatry
Subjects:
autism spectrum disorders
Shank3
PET
mGluR5
immunoblotting
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00038/full

Internet

https://www.frontiersin.org/article/10.3389/fpsyt.2019.00038/full

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