The IGF-1R Inhibitor NVP-AEW541 Causes Insulin-Independent and Reversible Cardiac Contractile Dysfunction

The IGF-1R Inhibitor NVP-AEW541 Causes Insulin-Independent and Reversible Cardiac Contractile Dysfunction

The antitumor treatment NVP-AEW541 blocks IGF-1R. IGF-1R signaling is crucial for cardiac function, but the cardiac effects of NVP-AEW541 are ill defined. We assessed NVP-AEW541′s effects on cardiac function and insulin response in vivo and in isolated working hearts. We performed a dose–response an...

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Bibliographic Details
Main Authors: Christina Schenkl, Andrea Schrepper, Estelle Heyne, Torsten Doenst, Michael Schwarzer
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
NVP-AEW541
small molecule
cardiac function
cardiac substrate oxidation
insulin-like growth factor 1
insulin resistance
Online Access:https://www.mdpi.com/2227-9059/10/8/2022

Internet

https://www.mdpi.com/2227-9059/10/8/2022

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