Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches
Abstract Autophagy is an evolutionarily conserved process that plays a role in regulating homeostasis under physiological conditions. However, dysregulation of autophagy is observed in the development of human diseases, especially cancer. Autophagy has reciprocal functions in cancer and may be respo...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01053-z |
| _version_ | 1811165792643842048 |
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| author | Mehrdad Hashemi Niloufar Nadafzadeh Mohammad Hassan Imani Romina Rajabi Setayesh Ziaolhagh Seyedeh Delaram Bayanzadeh Raheleh Norouzi Reihaneh Rafiei Zeinab Khazaei Koohpar Behnaz Raei Mohammad Arad Zandieh Shokooh Salimimoghadam Maliheh Entezari Afshin Taheriazam Athanasios Alexiou Marios Papadakis Shing Cheng Tan |
| author_facet | Mehrdad Hashemi Niloufar Nadafzadeh Mohammad Hassan Imani Romina Rajabi Setayesh Ziaolhagh Seyedeh Delaram Bayanzadeh Raheleh Norouzi Reihaneh Rafiei Zeinab Khazaei Koohpar Behnaz Raei Mohammad Arad Zandieh Shokooh Salimimoghadam Maliheh Entezari Afshin Taheriazam Athanasios Alexiou Marios Papadakis Shing Cheng Tan |
| author_sort | Mehrdad Hashemi |
| collection | DOAJ |
| description | Abstract Autophagy is an evolutionarily conserved process that plays a role in regulating homeostasis under physiological conditions. However, dysregulation of autophagy is observed in the development of human diseases, especially cancer. Autophagy has reciprocal functions in cancer and may be responsible for either survival or death. Hepatocellular carcinoma (HCC) is one of the most lethal and common malignancies of the liver, and smoking, infection, and alcohol consumption can lead to its development. Genetic mutations and alterations in molecular processes can exacerbate the progression of HCC. The function of autophagy in HCC is controversial and may be both tumor suppressive and tumor promoting. Activation of autophagy may affect apoptosis in HCC and is a regulator of proliferation and glucose metabolism. Induction of autophagy may promote tumor metastasis via induction of EMT. In addition, autophagy is a regulator of stem cell formation in HCC, and pro-survival autophagy leads to cancer cell resistance to chemotherapy and radiotherapy. Targeting autophagy impairs growth and metastasis in HCC and improves tumor cell response to therapy. Of note, a large number of signaling pathways such as STAT3, Wnt, miRNAs, lncRNAs, and circRNAs regulate autophagy in HCC. Moreover, regulation of autophagy (induction or inhibition) by antitumor agents could be suggested for effective treatment of HCC. In this paper, we comprehensively review the role and mechanisms of autophagy in HCC and discuss the potential benefit of targeting this process in the treatment of the cancer. Graphical abstract Video Abstract |
| first_indexed | 2024-04-10T15:42:49Z |
| format | Article |
| id | doaj.art-b7ba3c78725e4233b877f13029e779fc |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-10T15:42:49Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-b7ba3c78725e4233b877f13029e779fc2023-02-12T12:18:07ZengBMCCell Communication and Signaling1478-811X2023-02-0121112210.1186/s12964-023-01053-zTargeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approachesMehrdad Hashemi0Niloufar Nadafzadeh1Mohammad Hassan Imani2Romina Rajabi3Setayesh Ziaolhagh4Seyedeh Delaram Bayanzadeh5Raheleh Norouzi6Reihaneh Rafiei7Zeinab Khazaei Koohpar8Behnaz Raei9Mohammad Arad Zandieh10Shokooh Salimimoghadam11Maliheh Entezari12Afshin Taheriazam13Athanasios Alexiou14Marios Papadakis15Shing Cheng Tan16Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad UniversityFaculty of Veterinary Medicine, Science and Research Branch, Islamic Azad UniversityDepartment of Clinical Science, Faculty of Veterinary Medicine, Shahr-E Kord Branch, Islamic Azad UniversityFaculty of Veterinary Medicine, Science and Research Branch, Islamic Azad UniversityFaculty of Veterinary Medicine, Science and Research Branch, Islamic Azad UniversityFaculty of Veterinary Medicine, Science and Research Branch, Islamic Azad UniversityFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad UniversityFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad UniversityDepartment of Cell and Molecular Biology, Faculty of Biological Sciences, Tonekabon Branch, Islamic Azad UniversityFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad UniversityDepartment of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of TehranDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of AhvazDepartment of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad UniversityFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad UniversityDepartment of Science and Engineering, Novel Global Community Educational FoundationDepartment of Surgery II, University Hospital Witten-Herdecke, University of Witten-HerdeckeUKM Medical Molecular Biology Institute, Universiti Kebangsaan MalaysiaAbstract Autophagy is an evolutionarily conserved process that plays a role in regulating homeostasis under physiological conditions. However, dysregulation of autophagy is observed in the development of human diseases, especially cancer. Autophagy has reciprocal functions in cancer and may be responsible for either survival or death. Hepatocellular carcinoma (HCC) is one of the most lethal and common malignancies of the liver, and smoking, infection, and alcohol consumption can lead to its development. Genetic mutations and alterations in molecular processes can exacerbate the progression of HCC. The function of autophagy in HCC is controversial and may be both tumor suppressive and tumor promoting. Activation of autophagy may affect apoptosis in HCC and is a regulator of proliferation and glucose metabolism. Induction of autophagy may promote tumor metastasis via induction of EMT. In addition, autophagy is a regulator of stem cell formation in HCC, and pro-survival autophagy leads to cancer cell resistance to chemotherapy and radiotherapy. Targeting autophagy impairs growth and metastasis in HCC and improves tumor cell response to therapy. Of note, a large number of signaling pathways such as STAT3, Wnt, miRNAs, lncRNAs, and circRNAs regulate autophagy in HCC. Moreover, regulation of autophagy (induction or inhibition) by antitumor agents could be suggested for effective treatment of HCC. In this paper, we comprehensively review the role and mechanisms of autophagy in HCC and discuss the potential benefit of targeting this process in the treatment of the cancer. Graphical abstract Video Abstracthttps://doi.org/10.1186/s12964-023-01053-zHepatocellular carcinomaAutophagyChemoresistanceMetastasisStemness |
| spellingShingle | Mehrdad Hashemi Niloufar Nadafzadeh Mohammad Hassan Imani Romina Rajabi Setayesh Ziaolhagh Seyedeh Delaram Bayanzadeh Raheleh Norouzi Reihaneh Rafiei Zeinab Khazaei Koohpar Behnaz Raei Mohammad Arad Zandieh Shokooh Salimimoghadam Maliheh Entezari Afshin Taheriazam Athanasios Alexiou Marios Papadakis Shing Cheng Tan Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches Cell Communication and Signaling Hepatocellular carcinoma Autophagy Chemoresistance Metastasis Stemness |
| title | Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches |
| title_full | Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches |
| title_fullStr | Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches |
| title_full_unstemmed | Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches |
| title_short | Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches |
| title_sort | targeting and regulation of autophagy in hepatocellular carcinoma revisiting the molecular interactions and mechanisms for new therapy approaches |
| topic | Hepatocellular carcinoma Autophagy Chemoresistance Metastasis Stemness |
| url | https://doi.org/10.1186/s12964-023-01053-z |
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