Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers

Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers

The human leukocyte antigen (HLA) system is a major factor controlling cancer immunosurveillance and response to immunotherapy, yet its status in pediatric cancers remains fragmentary. We determined high-confidence HLA genotypes in 576 children, adolescents and young adults with recurrent/refractory...

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Bibliographic Details
Main Authors: Wan Ching Lim, Maria Eugenia Marques Da Costa, Karine Godefroy, Eric Jacquet, Loren Gragert, Windy Rondof, Antonin Marchais, Naima Nhiri, Davide Dalfovo, Mathias Viard, Nizar Labaied, Asif M. Khan, Philippe Dessen, Alessandro Romanel, Claudia Pasqualini, Gudrun Schleiermacher, Mary Carrington, Laurence Zitvogel, Jean-Yves Scoazec, Birgit Geoerger, Jerome Salmon
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
pediatric cancers
refractory and recurrent solid tumors
immunogenetics
HLA
tumor immunity
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265469/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265469/full

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