Two mutations in the HR2 region of Newcastle disease virus fusion protein with a cleavage motif “RRQRRL” are critical for fusogenic activity

Two mutations in the HR2 region of Newcastle disease virus fusion protein with a cleavage motif “RRQRRL” are critical for fusogenic activity

Abstract Background Newcastle disease virus (NDV) causes severe diseases in avian species. Its fusion protein cleavage site (Fcs) is a major contributor to virulence and membrane fusion. Previous studies showed that a change from phenylalanine (F) to lysine (L) at position 117 of the virulent strain...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Yanhong Wang, Youkun Bi, Wanqi Yu, Ning Wei, Wenbin Wang, Qiaolin Wei, Xinglong Wang, Shuxia Zhang, Zengqi Yang, Sa Xiao
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: BMC 2017-09-01
Sarja:Virology Journal
Aiheet:
Newcastle disease virus
F protein cleavage site
Syncytium formation
Linkit:http://link.springer.com/article/10.1186/s12985-017-0851-0

Internet

http://link.springer.com/article/10.1186/s12985-017-0851-0

Samankaltaisia teoksia