Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit

Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit

ABSTRACT Human antibody-based immunity to influenza A virus is limited by antigenic drift resulting from amino acid substitutions in the hemagglutinin (HA) head domain. Glycan addition can cause large antigenic changes but is limited by fitness costs to viral replication. Here, we report that glycan...

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Bibliographic Details
Main Authors: Meghan O. Altman, Matthew Angel, Ivan Košík, Nídia S. Trovão, Seth J. Zost, James S. Gibbs, Lorenzo Casalino, Rommie E. Amaro, Scott E. Hensley, Martha I. Nelson, Jonathan W. Yewdell
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mBio
Subjects:
influenza
viral evolution
hemagglutinin
immune evasion
glycosylation
Online Access:https://journals.asm.org/doi/10.1128/mBio.00204-19

Internet

https://journals.asm.org/doi/10.1128/mBio.00204-19

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