Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents

Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents

The acute activation of kappa opioid receptors (KOPr) produces antinociceptive and anti-cocaine effects, however, their side-effects have limited further clinical development. Mesyl Sal B is a potent and selective KOPr analogue of Salvinorin A (Sal A), a psychoactive natural product isolated from th...

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Bibliographic Details
Main Authors: Bronwyn M. Kivell, Kelly F. Paton, Nitin Kumar, Aashish S. Morani, Aimee Culverhouse, Amy Shepherd, Susan A. Welsh, Andrew Biggerstaff, Rachel S. Crowley, Thomas E. Prisinzano
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
Salvinorin A
kappa opioid
locomotion
behavioral sensitization
conditioned taste aversion
forced swim test
depression
drug abuse
addiction
behavioral pharmacology
Online Access:http://www.mdpi.com/1420-3049/23/10/2602

Internet

http://www.mdpi.com/1420-3049/23/10/2602

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