Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine

Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine

Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pharmacologically active? First, we investigated the...

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Bibliografiska uppgifter
Huvudupphovsmän: Kristin Andrud, Hong Xing, Bjarne Gabrielsen, Linda Bloom, Vladimir Mahnir, Stephen Lee, Benedict T. Green, Jon Lindstrom, William Kem
Materialtyp: Artikel
Språk:English
Publicerad: MDPI AG 2019-10-01
Serie:Marine Drugs
Ämnen:
acetylcholine
alkaloid
anabaseine
bipyridyl
cholinergic
nicotine
nicotinic acetylcholine receptor
ring-chain tautomerism
toxin
Länkar:https://www.mdpi.com/1660-3397/17/11/614

Internet

https://www.mdpi.com/1660-3397/17/11/614

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