Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse

Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse

Dysfunctional sarcoplasmic reticulum Ca2+ handling is commonly observed in heart failure, and thought to contribute to arrhythmogenesis through several mechanisms. Some time ago we developed a cardiomyocyte-specific inducible SERCA2 knockout mouse, which is remarkable in the degree to which major ad...

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Bibliographic Details
Main Authors: Andrew G. Edwards, Halvor Mørk, Mathis K. Stokke, David B. Lipsett, Ivar Sjaastad, Sylvain Richard, Ole M. Sejersted, William E. Louch
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Physiology
Subjects:
early afterdepolarizations (EADs)
delayed afterdepolarizations
species
triggered activity
repolarization
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.744730/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.744730/full

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