Endothelial barrier dysfunction in systemic inflammation is mediated by soluble VE-cadherin interfering VE-PTP signaling

Endothelial barrier dysfunction in systemic inflammation is mediated by soluble VE-cadherin interfering VE-PTP signaling

Summary: Breakdown of endothelial barrier integrity determines organ dysfunction and outcome of patients with sepsis. Increased levels of soluble vascular endothelial (VE)-cadherin fragments (sVE-cadherin) have previously been linked with inflammation-induced loss of endothelial barrier function. We...

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Bibliographic Details
Main Authors: Juna-Lisa Knop, Natalie Burkard, Mahshid Danesh, Sebastian Kintrup, Thomas Dandekar, Mugdha Srivastava, Rebecca Springer, Matthias Hiermaier, Nana-Maria Wagner, Jens Waschke, Sven Flemming, Nicolas Schlegel
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223021260

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http://www.sciencedirect.com/science/article/pii/S2589004223021260

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