The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation

The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation

Metabolites have been reported not only to support the highly-demanding energetic needs of cancer cells but also as signalling regulators. Here, the authors show that the activity of the folate cycle enzyme MTHFD2 stimulates PD-L1 expression impairing T cell-mediated cytotoxicity and promoting tumou...

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Bibliographic Details
Main Authors: Man Shang, Huijie Yang, Ran Yang, Tao Chen, Yuan Fu, Yeyi Li, Xianlong Fang, Kangjian Zhang, Jianju Zhang, Hui Li, Xueping Cao, Jinfa Gu, Jianwen Xiao, Qi Zhang, Xinyuan Liu, Qiujing Yu, Ting Wang
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22173-5

Internet

https://doi.org/10.1038/s41467-021-22173-5

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