Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner

Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner

Despite the extensive use of hormonal methods as either contraception or menopausal hormone therapy (HT), there is very little known about the potential effects of these compounds on the cellular processes of the brain. Medroxyprogesterone Acetate (MPA) is a progestogen used globally in the hormonal...

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Bibliographic Details
Main Authors: Keyana N. Porter, Saumyendra N. Sarkar, Duaa A. Dakhlallah, Mya E. Vannoy, Dominic D. Quintana, James W. Simpkins
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
matrix metalloproteinases
medroxyprogesterone acetate
amyloid-beta (Aβ)
amyloid-beta (Aβ) degradation
Alzheimer’s disease
hormone therapy
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00092/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2020.00092/full

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