Inhibition of Integrin αvβ3-FAK-MAPK signaling constrains the invasion of T-ALL cells

Inhibition of Integrin αvβ3-FAK-MAPK signaling constrains the invasion of T-ALL cells

ABSTRACTThe role of adhesion receptor integrin αvβ3 in T-ALL was unclear. Firstly, we performed quantitative real-time PCR to assess medullary expression of integrin β3(ITGB3) in T-ALL patients and high ITGB3 expression was relevant with the central nervous system leukemia(CNSL) incidence. Decreasin...

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Bibliographic Details
Main Authors: Lan Huang, Yao Zhu, Qinglin Kong, Xianmin Guan, Xiaoying Lei, Luying Zhang, Hui Yang, Xinyuan Yao, Shaoyan Liang, Xizhou An, Jie Yu
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Cell Adhesion & Migration
Subjects:
Cell invasion
central nervous system infiltration
FAK
integrin β3
T-ALL
Online Access:https://www.tandfonline.com/doi/10.1080/19336918.2023.2191913

Internet

https://www.tandfonline.com/doi/10.1080/19336918.2023.2191913

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